LymphedemaV1, PascalFrancis, Corpus, bibRecord, 000B78

The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs

Identifieur interne : 000B78 ( PascalFrancis/Corpus ); précédent : 000B77; suivant : 000B79

The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs

Auteurs : T. S. Chang ; J. L. Gan ; K. D. Fu ; W. Y. Huang

Source :

Lymphology [ 0024-7766 ] ; 1996.

RBID : Pascal:96-0478655

Descripteurs français

Pascal (Inist)
- Lymphoedème, Coumarine, Chauffage, Hyperfréquence, Chimiothérapie, Traitement, Association, Homme, Anticoagulant.

English descriptors

KwdEn :
- Anticoagulant, Association, Chemotherapy, Coumarin, Heating, Human, Lymphedema, Microwave, Treatment.

Abstract

Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10^-4) and improvement in circumferences and tonometry (p=10^-5 and 10^-7). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10^-7). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10^-9) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10^-9).

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0024-7766`
A02	`01`			`@0 LYMPBN`
A03		`1`		`@0 Lymphology`
A05				`@2 29`
A06				`@2 3`
A08	`01`	`1`	`ENG`	`@1 The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs`
A11	`01`	`1`		`@1 CHANG (T. S.)`
A11	`02`	`1`		`@1 GAN (J. L.)`
A11	`03`	`1`		`@1 FU (K. D.)`
A11	`04`	`1`		`@1 HUANG (W. Y.)`
A14	`01`			`@1 Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University @2 Shanghai @3 CHN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
A20				`@1 106-111`
A21				`@1 1996`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 14604 @5 354000066575310030`
A44				`@0 0000 @1 © 1996 INIST-CNRS. All rights reserved.`
A45				`@0 17 ref.`
A47	`01`	`1`		`@0 96-0478655`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Lymphology`
A66	`01`			`@0 INT`
C01	`01`		`ENG`	@0 Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10^-4) and improvement in circumferences and tonometry (p=10^-5 and 10^-7). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10^-7). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10^-9) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10^-9).
C02	`01`	`X`		`@0 002B02G`
C03	`01`	`X`	`FRE`	`@0 Lymphoedème @5 01`
C03	`01`	`X`	`ENG`	`@0 Lymphedema @5 01`
C03	`01`	`X`	`SPA`	`@0 Linfedema @5 01`
C03	`02`	`X`	`FRE`	`@0 Coumarine @2 NK @5 04`
C03	`02`	`X`	`ENG`	`@0 Coumarin @2 NK @5 04`
C03	`03`	`X`	`FRE`	`@0 Chauffage @5 07`
C03	`03`	`X`	`ENG`	`@0 Heating @5 07`
C03	`03`	`X`	`GER`	`@0 Erhitzen @5 07`
C03	`03`	`X`	`SPA`	`@0 Calefacción @5 07`
C03	`04`	`X`	`FRE`	`@0 Hyperfréquence @5 10`
C03	`04`	`X`	`ENG`	`@0 Microwave @5 10`
C03	`04`	`X`	`GER`	`@0 Mikrowelle @5 10`
C03	`04`	`X`	`SPA`	`@0 Hiperfrecuencia @5 10`
C03	`05`	`X`	`FRE`	`@0 Chimiothérapie @5 16`
C03	`05`	`X`	`ENG`	`@0 Chemotherapy @5 16`
C03	`05`	`X`	`SPA`	`@0 Quimioterapia @5 16`
C03	`06`	`X`	`FRE`	`@0 Traitement @5 17`
C03	`06`	`X`	`ENG`	`@0 Treatment @5 17`
C03	`06`	`X`	`GER`	`@0 Aufbereiten @5 17`
C03	`06`	`X`	`SPA`	`@0 Tratamiento @5 17`
C03	`07`	`X`	`FRE`	`@0 Association @5 18`
C03	`07`	`X`	`ENG`	`@0 Association @5 18`
C03	`07`	`X`	`SPA`	`@0 Asociación @5 18`
C03	`08`	`X`	`FRE`	`@0 Homme @5 20`
C03	`08`	`X`	`ENG`	`@0 Human @5 20`
C03	`08`	`X`	`SPA`	`@0 Hombre @5 20`
C03	`09`	`X`	`FRE`	`@0 Anticoagulant @5 27`
C03	`09`	`X`	`ENG`	`@0 Anticoagulant @5 27`
C03	`09`	`X`	`SPA`	`@0 Anticoagulante @5 27`
C07	`01`	`X`	`FRE`	`@0 Appareil circulatoire pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Cardiovascular disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Lymphatique pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Lymphatic vessel disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Linfático patología @5 38`
N21				`@1 330`

Format Inist (serveur)

NO :	PASCAL 96-0478655 INIST
ET :	The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs
AU :	CHANG (T. S.); GAN (J. L.); FU (K. D.); HUANG (W. Y.)
AF :	Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University/Shanghai/Chine (1 aut., 2 aut., 3 aut., 4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Lymphology; ISSN 0024-7766; Coden LYMPBN; International; Da. 1996; Vol. 29; No. 3; Pp. 106-111; Bibl. 17 ref.
LA :	Anglais
EA :	Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10^-4) and improvement in circumferences and tonometry (p=10^-5 and 10^-7). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10^-7). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10^-9) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10^-9).
CC :	002B02G
FD :	Lymphoedème; Coumarine; Chauffage; Hyperfréquence; Chimiothérapie; Traitement; Association; Homme; Anticoagulant
FG :	Appareil circulatoire pathologie; Lymphatique pathologie
ED :	Lymphedema; Coumarin; Heating; Microwave; Chemotherapy; Treatment; Association; Human; Anticoagulant
EG :	Cardiovascular disease; Lymphatic vessel disease
GD :	Erhitzen; Mikrowelle; Aufbereiten
SD :	Linfedema; Calefacción; Hiperfrecuencia; Quimioterapia; Tratamiento; Asociación; Hombre; Anticoagulante
LO :	INIST-14604.354000066575310030
ID :	96-0478655

Links to Exploration step

Pascal:96-0478655

Le document en format XML

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<term>Lymphedema</term>
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<front><div type="abstract" xml:lang="en">Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10<sup>-4</sup>
) and improvement in circumferences and tonometry (p=10<sup>-5</sup>
 and 10<sup>-7</sup>
). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10<sup>-7</sup>
). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10<sup>-9</sup>
) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10<sup>-9</sup>
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<fC01 i1="01" l="ENG"><s0>Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10<sup>-4</sup>
) and improvement in circumferences and tonometry (p=10<sup>-5</sup>
 and 10<sup>-7</sup>
). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10<sup>-7</sup>
). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10<sup>-9</sup>
) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10<sup>-9</sup>
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<server><NO>PASCAL 96-0478655 INIST</NO>
<ET>The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs</ET>
<AU>CHANG (T. S.); GAN (J. L.); FU (K. D.); HUANG (W. Y.)</AU>
<AF>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University/Shanghai/Chine (1 aut., 2 aut., 3 aut., 4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Lymphology; ISSN 0024-7766; Coden LYMPBN; International; Da. 1996; Vol. 29; No. 3; Pp. 106-111; Bibl. 17 ref.</SO>
<LA>Anglais</LA>
<EA>Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10<sup>-4</sup>
) and improvement in circumferences and tonometry (p=10<sup>-5</sup>
 and 10<sup>-7</sup>
). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10<sup>-7</sup>
). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10<sup>-9</sup>
) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10<sup>-9</sup>
).</EA>
<CC>002B02G</CC>
<FD>Lymphoedème; Coumarine; Chauffage; Hyperfréquence; Chimiothérapie; Traitement; Association; Homme; Anticoagulant</FD>
<FG>Appareil circulatoire pathologie; Lymphatique pathologie</FG>
<ED>Lymphedema; Coumarin; Heating; Microwave; Chemotherapy; Treatment; Association; Human; Anticoagulant</ED>
<EG>Cardiovascular disease; Lymphatic vessel disease</EG>
<GD>Erhitzen; Mikrowelle; Aufbereiten</GD>
<SD>Linfedema; Calefacción; Hiperfrecuencia; Quimioterapia; Tratamiento; Asociación; Hombre; Anticoagulante</SD>
<LO>INIST-14604.354000066575310030</LO>
<ID>96-0478655</ID>
</server>
</inist>
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The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs

The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs

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